Boston Startup Hub

Welcome to the hub for the most groundbreaking and ambitious startups in Boston! Our directory has just landed, want to join us on this exciting journey?

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Featured Startups

Dive into our directory to uncover more innovations that are shaping the city's future.

Mainstay

At Mainstay, we believe one conversation can spark a brighter future. Our Engagement Platform makes it easy for colleges and businesses to start and measure conversations that drive action at scale. From our rigorous research methods to our Behavioral Intelligence framework — everything we do is designed to help people take the next step toward achieving their goals.

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Rezonate

Software

Rezonate

Rezonate.io is a cutting-edge Identity Centric Security Platform designed to fortify both human and machine identities against cyber threats throughout their entire access journey to business assets. With a bold proclamation that "A/B Testing is Dead," Rezonate.io champions a shift from traditional methods to AI-driven solutions. Their platform offers comprehensive features such as real-time monitoring of privileges and activities, risk reduction, and active threat mitigation. Recognized as a "Cool Vendor" in the 2023 Gartner® Cool Vendors™ in Identity-First Security report, Rezonate.io is committed to delivering an all-encompassing identity-first security platform that bolsters security posture, fortifies defense mechanisms, and facilitates effective threat remediation. Rezonate.io's platform is uniquely designed to discover, profile, and protect identities, ensuring secure access to cloud infrastructure and critical SaaS applications. It provides continuous exposure reduction by uncovering and rectifying weak authentication, misconfigured trust relations, and other vulnerabilities. Moreover, the platform's adaptive access engine optimizes security controls, ensuring that identities are managed efficiently.

Entrada Therapeutics

Biotech

Entrada Therapeutics

Headquartered in Boston’s Seaport community, Entrada Therapeutics is a growing biopharmaceutical company innovating to transform the treatment of devastating diseases through intracellular therapeutics. We’re establishing a new class of medicines, Endosomal Escape Vehicles (EEV™), with the potential to engage intracellular targets that have long been considered inaccessible and undruggable. Our EEV™ therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues with an improved therapeutic index.

JellyFish

Software

JellyFish

Jellyfish is the pioneer Engineering Management Platform that enables engineering leaders to align engineering work with strategic business objectives. By analyzing engineering signals and contextual business data, Jellyfish provides complete visibility into engineering organizations, the work they do, and how they operate. Companies like SessionM (A Mastercard Company) and Toast use Jellyfish to optimize the allocation of engineering resources to focus their teams on what matters most to the business.

Hourwork

HR Tech

Hourwork

HourWork offers a new, better way to hire and retain hourly workers in today’s understaffed world. Our best-in-class recruitment and retention solutions help match employers with top hourly talent, uncover what matters most to employees, and automatically check in at key milestones to prevent early attrition. Our name is rooted in our commitment to celebrate and build the interdependent relationship between employers and employees. We partner with clients who see themselves as skill providers and who have a deep belief that their business is most successful when their employees feel successful, too. This understanding – coupled with our advanced HourWork technology – differentiates our customers from the abundance of employers ready to hire today as an employer of choice.

Guidesly

Consumer

Guidesly

Experience the great outdoors with Guidesly - the next-generation marketplace that connects you with expert guides for a variety of outdoor activities, from fishing and hunting to ATV/UTV and more. Our website and app (Guidesly Trips) make it easy for you to compare and book trusted guides and discover the perfect adventure tailored to your interests and skill level. Leave the planning to us and trust our experienced guides to lead the way. Guidesly also supports guides by providing innovative solutions to common challenges faced in the outdoor guiding business. Our platform offers powerful tools for guides to manage their businesses more efficiently and effectively so they can focus on what matters most - delivering unforgettable experiences to their guests. Join our community of passionate outdoor enthusiasts and start your next adventure with Guidesly.

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Latest News

Dive into our blog for the latest trends and success stories from the Boston's startup community.

July 22nd, 2025

Boston Tech Talks: Arnar Larusson from Tyme Wear

In this edition of Boston Tech Talks, Arnar Larusson, co-founder of Tyme Wear, shares how his background in biomechanics and engineering led to building a wearable tech startup—and why Boston’s unique mix of resources, talent, and community made it the ideal place to launch.